Jim the Pleb Made Me Do It

[Apples]

90% of their effort goes to ripping into Ophelia Benson and Stephanie Zvan with 9% of the remaining going to PZ Myers. Crommunist, for example, has nothing nice to say about the pit and writes in what I would describe as a much more aggressive style, yet there aren’t any racial attacks on him.

You don’t find this at all odd?

I'm amazed by this nugget. It's sometimes quite a strain to follow baboon "logic." Doubthat is apparently trying to assert that 'pitters are misogynists by calling us out for not being not racists? The mind boggles.

For the record, Crommie is a dick who has extremely convoluted and problematic views about race and social justice, but his blog gets little attention, he mentions the 'Pit rarely, and his guestblogger Half-fish is a better source of lulz. As for doubthat's dubious claim that he has a "more aggressive style" than Benson/Svan, I'll refrain from a SJW deconstruction of that statement.

http://www.michaelnugent.com/2013/03/07 ... ent-197396

[Steersman]

If you want a break from the tone trolling of Michael Nugent. Clean energy is near and dear to me and medical radioactive isotopes to treat cancers are in terribly short supply.

That was awesome - thanks for posting it!

I read some good news today regarding cancer treatment research. Years ago, as a postdoc, I developed and characterized a genetically engineered mouse model (GEMM) for an aggressive form of inherited cancer. It typically affects people who have the cancer syndrome when they're in their teens, or as young adults, and it is nearly impossible to treat effectively. Doesn't respond well to chemotherapy or radiotherapy (and the patient has a high risk of developing a secondary malignancy as a result of the treatment), and very difficult to remove completely with surgery. Over the years, with a number of collaborators, we used the GEMM to identify genes that might provide therapeutic targets. My lab looked at the genomic instability of the tumors, and of tissues that might develop secondary malignancies following radio- or chemotherapy to treat the primary tumor.

Well, today a friend sent me a link to a paper indicating that my postdoc mentor's current lab group has cured the tumors in the GEMM, with both genetic and pharmacological approaches. Cured them. Gone! Their next step is a clinical trial in humans who have this type of cancer, with the pharmacologic agent. Go SCIENCE!!!! :dance:

Congrats; bloody good show, eh! :-)

Must feel rather gratifying, to have been a significant part of that process – “one small [?] step for a woman; one rather large step for humanity” – and all that.

Out of curiousity, any links to that paper available or to related discussions? ….

[Lurkion]

Thanks for pointing that out ReneeHendricks. I genuinely feel bad for O. Benson.

For the record so do I. This is an example of genuine harassment in my opinion. If she makes hay out of it I would not blame her one bit.

In one of my posts I opened with the statement that he was not only feeding the troll but in his eagerness to score points publicising something distasteful. At that time I did not know if he had Benson's permission to do so but if he did not his behaviour is reprehensible.

What? Are you saying Nugent is harassing OB?

[another lurker]

Thanks for pointing that out ReneeHendricks. I genuinely feel bad for O. Benson.

For the record so do I. This is an example of genuine harassment in my opinion. If she makes hay out of it I would not blame her one bit.

In one of my posts I opened with the statement that he was not only feeding the troll but in his eagerness to score points publicising something distasteful. At that time I did not know if he had Benson's permission to do so but if he did not his behaviour is reprehensible.

What? Are you saying Nugent is harassing OB?

Seems to me that Ophie's feelings matter less than scoring points for the SJW side.

[nippletwister]

90% of their effort goes to ripping into Ophelia Benson and Stephanie Zvan with 9% of the remaining going to PZ Myers. Crommunist, for example, has nothing nice to say about the pit and writes in what I would describe as a much more aggressive style, yet there aren’t any racial attacks on him.

You don’t find this at all odd?

I'm amazed by this nugget. It's sometimes quite a strain to follow baboon "logic." Doubthat is apparently trying to assert that 'pitters are misogynists by calling us out for not being not racists? The mind boggles.

For the record, Crommie is a dick who has extremely convoluted and problematic views about race and social justice, but his blog gets little attention, he mentions the 'Pit rarely, and his guestblogger Half-fish is a better source of lulz. As for doubthat's dubious claim that he has a "more aggressive style" than Benson/Svan, I'll refrain from a SJW deconstruction of that statement.

http://www.michaelnugent.com/2013/03/07 ... ent-197396

I for one have complained, here and elsewhere, about both Crommunist and Sikivu. I think they are occasionally thoughtful but silly dingbats who are more race-obsessed than most klan members. And Crommunist is also not very charitable in his readings of other people, yet expects to be taken perfectly seriously himself. And Half-Fish is a goddamned lunatic, but that's who you get in circles like those.

[Gefan]

Setár, genderqueer Elf-Sheriff of Atheism+
"They can have their Slymepit, where they can engage in their Tea Party rhetoric towards PZ and Stephanie and all sorts of other wonderful feminist skeptics. History is on the move; if they do not wish to keep up we can leave them behind to watch from a distance."

Please can everyone wave nicely for once. No rude gestures this time, y'all hear? Tx :violin:

What color is the sky in Setar's little world or is it perpetually obscured by bong smoke?

[Apples]

Meanwhile, the Skepchicks have yet to come up with a Thursday Bad Graph post, or whatever it was that Becky Whatnot called her radical new idea.

Seriously, it's like the entire FfTB and Skepchick crew are a load of Poes, like a bunch of religionists pretending to be atheists to discredit us by behaving like complete fucking idiots, freeloaders and general cunts.

I'm honestly rooting for Becky, someday, to come up with a genuine quality Bad Graph (one of her favorite Skepchick features!) that intelligently illuminates the way data can be misrepresented, but so far she's reminding me of some of the more dysfunctional workplaces I've known -- come up with a decent sales/marketing gimmick that actually takes work, proceed to be too lazy to implement it yourself and too incompetent to delegate it properly; at midnight, assign to lackey who does a clumsy job of it. Repeat the following week until the idea implodes under the pressure of its shitty implementation.

You're right -- the FTB/A+/Skepchick crowd are so subpar when it comes to competent critical thinking and realization of their purported goals/values that the whole thing almost feels like a long con.

[BarnOwl]

Congrats; bloody good show, eh! :-)

Must feel rather gratifying, to have been a significant part of that process – “one small [?] step for a woman; one rather large step for humanity” – and all that.

Out of curiousity, any links to that paper available or to related discussions? ….

Linky to PubMed abstract for the paper: http://www.ncbi.nlm.nih.gov/pubmed/23434321

Linky to news article: http://www.alnmag.com/news/mouse-model- ... ncer-cured

[Gefan]

I think I just ruptured an organ laughing.

Ellenbeth just Goatse'd Michael's thread. :lol: :lol: :lol:

You think you have problems? I'm weeping tears of laughter into my Johnny Walker and about to get thrown out of a hotel bar.

[rayshul]

Well, today a friend sent me a link to a paper indicating that my postdoc mentor's current lab group has cured the tumors in the GEMM, with both genetic and pharmacological approaches. Cured them. Gone! Their next step is a clinical trial in humans who have this type of cancer, with the pharmacologic agent. Go SCIENCE!!!! :dance:

Awesome :) That's brilliant news.

[katamari Damassi]

This place is next to impossible to keep up with.

I see another troll or plant(oolon?)did another bad naked old woman photoshop of Ophie. I don't find nudes offensive but I don't see the point of posting those. It's just not funny. For the record I agree with Luomo's actions on this.

I see Nugent has confirmed that he is the disingenuous dickhead we all suspected him of being.

Ericthebassest is a fellow Buffalonian, so he can't be all bad. Hey Eric if you're still around, let me know what bars you'll be playing. I promise that in the event that I think you suck, I'll keep my opinion to myself. I hope you'll appreciate the sort of effort that requires of me.

[Gefan]

Thanks for pointing that out ReneeHendricks. I genuinely feel bad for O. Benson.

She seemed depressed the other day and this just seems to have made it worse. It's not much and it may seem hypocritical to some but I donated $10 to her fund. I figure she can go out and get a coffee or two or those cookies she goes on about - whatever brings a small smile, you know?

Cue Ophelia Fluevogs purchase in 3, 2, 1...

[decius]

http://s14.postimage.org/acck67869/Sam_Harrius.jpg

[JackSkeptic]

Thanks for pointing that out ReneeHendricks. I genuinely feel bad for O. Benson.

For the record so do I. This is an example of genuine harassment in my opinion. If she makes hay out of it I would not blame her one bit.

In one of my posts I opened with the statement that he was not only feeding the troll but in his eagerness to score points publicising something distasteful. At that time I did not know if he had Benson's permission to do so but if he did not his behaviour is reprehensible.

What? Are you saying Nugent is harassing OB?

Yes he is contributing to it in a very big way. I referred to it as the Streisand Effect in my post there and feeding the troll.

[rayshul]

Yes he is contributing to it in a very big way. I referred to it as the Streisand Effect in my post there and feeding the troll.

I wouldn't say it's intentional or anything like that ... but it's the same sort of thing that happens when PZ says oh I don't want to trigger rape victims, I'm just going to hunt all over the internet for people talking about rape!

[Steersman]

Congrats; bloody good show, eh! :-)

Must feel rather gratifying, to have been a significant part of that process – “one small [?] step for a woman; one rather large step for humanity” – and all that.

Out of curiousity, any links to that paper available or to related discussions? ….

Linky to PubMed abstract for the paper: http://www.ncbi.nlm.nih.gov/pubmed/23434321

Linky to news article: http://www.alnmag.com/news/mouse-model- ... ncer-cured

Thanks muchly ....

[Steersman]

Thanks for pointing that out ReneeHendricks. I genuinely feel bad for O. Benson.

For the record so do I. This is an example of genuine harassment in my opinion. If she makes hay out of it I would not blame her one bit.

In one of my posts I opened with the statement that he was not only feeding the troll but in his eagerness to score points publicising something distasteful. At that time I did not know if he had Benson's permission to do so but if he did not his behaviour is reprehensible.

What? Are you saying Nugent is harassing OB?

Yes he is contributing to it in a very big way. I referred to it as the Streisand Effect in my post there and feeding the troll.

Kind of like declaring war on Nazi Germany for the invasion of Poland contributed to the deaths of some additional ten to thirty million people?

Eggs, omlettes, and all that ….

[katamari Damassi]

I for one have complained, here and elsewhere, about both Crommunist and Sikivu. I think they are occasionally thoughtful but silly dingbats who are more race-obsessed than most klan members. And Crommunist is also not very charitable in his readings of other people, yet expects to be taken perfectly seriously himself. And Half-Fish is a goddamned lunatic, but that's who you get in circles like those.

I agree with you. I never had anything against Crommie until he started trolling his own blog with the Crying Shark and then rewriting posted comments without noting that he had rewritten someone else's posted comments.
Sikivu (aka: Sickofyou, aka: Discount Angela Davis)I never had much love for. She's a bit of a conspiracy theorist, quick to imply that people who disagree with her opinions are racist, and reminds me of those overly ernest young people you see at poetry slams "speaking troof to power."

[karlaporter]

Thanks for pointing that out ReneeHendricks. I genuinely feel bad for O. Benson.

She seemed depressed the other day and this just seems to have made it worse. It's not much and it may seem hypocritical to some but I donated $10 to her fund. I figure she can go out and get a coffee or two or those cookies she goes on about - whatever brings a small smile, you know?

Cue Ophelia Fluevogs purchase in 3, 2, 1...

Awesome idea, I'm going to get in on that good vibe too =) Cookie time!!

[Gefan]

I don't think it can be emphasized enough that civil attempts at discussion have been made MANY MANY times, and are STILL being attempted (Justin Vacula being one example). It might surprise you but many of the people here were driven here after engaging in good faith at FTB or elsewhere...

I have great respect for Justin's patience, forbearance, and fortitude but I still don't see the need to engage. Look at the trajectory of traffic and membership here compared to FTB and A+. The defections are all in the same direction. To reiterate an earlier point, if you can remember the Cold War you should know that this can only end one way.

[rayshul]

I for one have complained, here and elsewhere, about both Crommunist and Sikivu. I think they are occasionally thoughtful but silly dingbats who are more race-obsessed than most klan members. And Crommunist is also not very charitable in his readings of other people, yet expects to be taken perfectly seriously himself. And Half-Fish is a goddamned lunatic, but that's who you get in circles like those.

I agree with you. I never had anything against Crommie until he started trolling his own blog with the Crying Shark and then rewriting posted comments without noting that he had rewritten someone else's posted comments.
Sikivu (aka: Sickofyou, aka: Discount Angela Davis)I never had much love for. She's a bit of a conspiracy theorist, quick to imply that people who disagree with her opinions are racist, and reminds me of those overly ernest young people you see at poetry slams "speaking troof to power."

I quit reading RDnet when they started to promote her stuff. She's truly repulsive.

[decius]

RD.net not new at these stunts. They put atheism ahead of rationalism and that's a terrible mistake, in my opinion.

[Mzone]

If you want a break from the tone trolling of Michael Nugent. Clean energy is near and dear to me and medical radioactive isotopes to treat cancers are in terribly short supply.

That was awesome - thanks for posting it!

I read some good news today regarding cancer treatment research. Years ago, as a postdoc, I developed and characterized a genetically engineered mouse model (GEMM) for an aggressive form of inherited cancer. It typically affects people who have the cancer syndrome when they're in their teens, or as young adults, and it is nearly impossible to treat effectively. Doesn't respond well to chemotherapy or radiotherapy (and the patient has a high risk of developing a secondary malignancy as a result of the treatment), and very difficult to remove completely with surgery. Over the years, with a number of collaborators, we used the GEMM to identify genes that might provide therapeutic targets. My lab looked at the genomic instability of the tumors, and of tissues that might develop secondary malignancies following radio- or chemotherapy to treat the primary tumor.

Well, today a friend sent me a link to a paper indicating that my postdoc mentor's current lab group has cured the tumors in the GEMM, with both genetic and pharmacological approaches. Cured them. Gone! Their next step is a clinical trial in humans who have this type of cancer, with the pharmacologic agent. Go SCIENCE!!!! :dance:

Anytime BarnOwl :) I am glad someone enjoyed it.

As for your mentor, that sounds like great news! Any views on http://www.nytimes.com/2013/02/12/scien ... anted=all&

I am hoping that GEMM is still a valid testing model for Cancer.

Mzone

[jimthepleb]

I don't think it can be emphasized enough that civil attempts at discussion have been made MANY MANY times, and are STILL being attempted (Justin Vacula being one example). It might surprise you but many of the people here were driven here after engaging in good faith at FTB or elsewhere...

I have great respect for Justin's patience, forbearance, and fortitude but I still don't see the need to engage. Look at the trajectory of traffic and membership here compared to FTB and A+. The defections are all in the same direction. To reiterate an earlier point, if you can remember the Cold War you should know that this can only end one way.

The fall of the berlin wall and the invasion of afghanistan and iraq? I don't see it coming to that (but i have heard that FtB are developing nuclear capability)

[decius]

Barnowl, that looks promising. Congratulations.

[Bourne Skeptic]

I don't think it can be emphasized enough that civil attempts at discussion have been made MANY MANY times, and are STILL being attempted (Justin Vacula being one example). It might surprise you but many of the people here were driven here after engaging in good faith at FTB or elsewhere...

I have great respect for Justin's patience, forbearance, and fortitude but I still don't see the need to engage. Look at the trajectory of traffic and membership here compared to FTB and A+. The defections are all in the same direction. To reiterate an earlier point, if you can remember the Cold War you should know that this can only end one way.

The fall of the berlin wall and the invasion of afghanistan and iraq? I don't see it coming to that (but i have heard that FtB are developing nuclear capability)

I heard it was a biological weapon, something having to do with PZ's socks!

[JackSkeptic]

Yes he is contributing to it in a very big way. I referred to it as the Streisand Effect in my post there and feeding the troll.

I wouldn't say it's intentional or anything like that ... but it's the same sort of thing that happens when PZ says oh I don't want to trigger rape victims, I'm just going to hunt all over the internet for people talking about rape!

Not intentional but very, very, very stupid, unless he had permission which I naturally assumed he did at first. Anyone with one brain cell would have known how it would have gone, he had evidence of that already the last few days.

Anyway I think Atheist Ireland are starting to grasp how trying to get involved in an overseas dispute is a very bad idea. He was warned that his approach sucked and he ignored it. He clearly failed at even basic research. Before he did that stupid post today I was starting to think that maybe he was getting it. I was wrong.

I also think he is a prime example of the Dunning-Kreugar effect in action. He really thought people here were mindless trolls and moral delinquents.

Atheist Ireland will now pay the price for his actions. I can't be any more charitable than that although I have tried. He was warned by numerous people from the start. The best thing he can do now is drop it and pretend it never happened as he has lost a considerable amount of credibility and, unfortunately by association, so has his organisation. That is a real shame. He may also be more mindful of the speakers he chooses for conferences, he's walked straight into a bunch of people who will think nothing of smearing him and his associates if they can get advantage from doing so, as Aratina and Spokesgay have already shown.

[Gefan]

...but i have heard that FtB are developing nuclear capability)

You forget, all the actual scientists are on our side (although the Vice President's office claims knowledge os suspicious purchases of Mentos and Coke from Niger).

[BarnOwl]

Anytime BarnOwl :) I am glad someone enjoyed it.

As for your mentor, that sounds like great news! Any views on http://www.nytimes.com/2013/02/12/scien ... anted=all&

I am hoping that GEMM is still a valid testing model for Cancer.

Mzone

It depends on the type of cancer and the genes involved, and you have to be very, very careful with your characterization and interpretations. You can knock out a gene that's associated with a specific type of cancer in humans, and it might cause cancer in a completely different tissue in the mouse. Or knocking out the gene might not cause any type of cancer in the mouse, or the cancer might occur with very different timing or aggressiveness. The relationship between two mutated genes on the chromosome (cis or trans, believe it or not :D ) can be important - that was certainly the case for our GEMM. I spent what seemed like eons in the lab characterizing the tumors, making cell lines from tumors and characterizing those, aging the tumor mice (and 5 different control genotypes of mice) and monitoring survival, etc. before we could even think about submitting a manuscript.

[Badger3k]

I don't think it can be emphasized enough that civil attempts at discussion have been made MANY MANY times, and are STILL being attempted (Justin Vacula being one example). It might surprise you but many of the people here were driven here after engaging in good faith at FTB or elsewhere...

I have great respect for Justin's patience, forbearance, and fortitude but I still don't see the need to engage. Look at the trajectory of traffic and membership here compared to FTB and A+. The defections are all in the same direction. To reiterate an earlier point, if you can remember the Cold War you should know that this can only end one way.

The fall of the berlin wall and the invasion of afghanistan and iraq? I don't see it coming to that (but i have heard that FtB are developing nuclear capability)

I heard it was a biological weapon, something having to do with PZ's socks!

Not coffee? Or is that our weapon? I forgot to check my backchannel - it was a bit blocked, so I may not have gotten the message.

Should our new motto be "Mr Myers, tear down that wall"?

[ConcentratedH2O, OM]

Well, today a friend sent me a link to a paper indicating that my postdoc mentor's current lab group has cured the tumors in the GEMM, with both genetic and pharmacological approaches. Cured them. Gone! Their next step is a clinical trial in humans who have this type of cancer, with the pharmacologic agent. Go SCIENCE!!!! :dance:

Awesome :) That's brilliant news.

Barnowl: what's the disease, unless you feel that would lead to your identification and that that would not be to your liking.

I think that sentence needs to be followed by : (((((((gentle hugs)))))))) if you want them.

[justinvacula]

Well, today a friend sent me a link to a paper indicating that my postdoc mentor's current lab group has cured the tumors in the GEMM, with both genetic and pharmacological approaches. Cured them. Gone! Their next step is a clinical trial in humans who have this type of cancer, with the pharmacologic agent. Go SCIENCE!!!! :dance:

Awesome :) That's brilliant news.

Barnowl: what's the disease, unless you feel that would lead to your identification and that that would not be to your liking.

I think that sentence needs to be followed by : (((((((gentle hugs)))))))) if you want them.

Don't steal my hugs!

[BarnOwl]

Well, today a friend sent me a link to a paper indicating that my postdoc mentor's current lab group has cured the tumors in the GEMM, with both genetic and pharmacological approaches. Cured them. Gone! Their next step is a clinical trial in humans who have this type of cancer, with the pharmacologic agent. Go SCIENCE!!!! :dance:

Awesome :) That's brilliant news.

Barnowl: what's the disease, unless you feel that would lead to your identification and that that would not be to your liking.

I think that sentence needs to be followed by : (((((((gentle hugs)))))))) if you want them.

Check the news article linky I posted above for Steersman.

[ConcentratedH2O, OM]

If you want a break from the tone trolling of Michael Nugent. Clean energy is near and dear to me and medical radioactive isotopes to treat cancers are in terribly short supply.

That was awesome - thanks for posting it!

I read some good news today regarding cancer treatment research. Years ago, as a postdoc, I developed and characterized a genetically engineered mouse model (GEMM) for an aggressive form of inherited cancer. It typically affects people who have the cancer syndrome when they're in their teens, or as young adults, and it is nearly impossible to treat effectively. Doesn't respond well to chemotherapy or radiotherapy (and the patient has a high risk of developing a secondary malignancy as a result of the treatment), and very difficult to remove completely with surgery. Over the years, with a number of collaborators, we used the GEMM to identify genes that might provide therapeutic targets. My lab looked at the genomic instability of the tumors, and of tissues that might develop secondary malignancies following radio- or chemotherapy to treat the primary tumor.

Well, today a friend sent me a link to a paper indicating that my postdoc mentor's current lab group has cured the tumors in the GEMM, with both genetic and pharmacological approaches. Cured them. Gone! Their next step is a clinical trial in humans who have this type of cancer, with the pharmacologic agent. Go SCIENCE!!!! :dance:

Anytime BarnOwl :) I am glad someone enjoyed it.

As for your mentor, that sounds like great news! Any views on http://www.nytimes.com/2013/02/12/scien ... anted=all&

I am hoping that GEMM is still a valid testing model for Cancer.

Mzone

Mzone: most scientists have always accepted that mice are not a perfect model of human diseases. How could they be? The only perfect model of human diseases is humans with those diseases. But it's really hard (impossible, outside of China) to get ethical approval to deliberately give 20 humans sepsis, and then try to cure them with a drug that no one has taken before. So, we make do with what we have.

This paper seems to make it clear just how different some diseases are between humans and mice. But, as I said, we make do with what we have while realizing that our models may be completely non-representative of the human equivalent.

[ConcentratedH2O, OM]

Well, today a friend sent me a link to a paper indicating that my postdoc mentor's current lab group has cured the tumors in the GEMM, with both genetic and pharmacological approaches. Cured them. Gone! Their next step is a clinical trial in humans who have this type of cancer, with the pharmacologic agent. Go SCIENCE!!!! :dance:

Awesome :) That's brilliant news.

Barnowl: what's the disease, unless you feel that would lead to your identification and that that would not be to your liking.

I think that sentence needs to be followed by : (((((((gentle hugs)))))))) if you want them.

Don't steal my hugs!

It's time to reprise this video!

[youtube]9C_11laqbvM[/youtube]

[lonesagi]

Congrats; bloody good show, eh! :-)

Must feel rather gratifying, to have been a significant part of that process – “one small [?] step for a woman; one rather large step for humanity” – and all that.

Out of curiousity, any links to that paper available or to related discussions? ….

Linky to PubMed abstract for the paper: http://www.ncbi.nlm.nih.gov/pubmed/23434321

Linky to news article: http://www.alnmag.com/news/mouse-model- ... ncer-cured

BarnOwl, thank you for your work in the field, and for the interesting reading!

[ConcentratedH2O, OM]

Well, today a friend sent me a link to a paper indicating that my postdoc mentor's current lab group has cured the tumors in the GEMM, with both genetic and pharmacological approaches. Cured them. Gone! Their next step is a clinical trial in humans who have this type of cancer, with the pharmacologic agent. Go SCIENCE!!!! :dance:

Awesome :) That's brilliant news.

Barnowl: what's the disease, unless you feel that would lead to your identification and that that would not be to your liking.

I think that sentence needs to be followed by : (((((((gentle hugs)))))))) if you want them.

Check the news article linky I posted above for Steersman.

Great, NF1 germline mutation is a (Trigger Warning) bitch, and I know Parada is a great scientist. Congrats.

(((((((((forced hugs from behind with a reacharound)))))))))))))

[jimthepleb]

...but i have heard that FtB are developing nuclear capability)

You forget, all the actual scientists are on our side (although the Vice President's office claims knowledge os suspicious purchases of Mentos and Coke from Niger).

I believe Thunderf00t has access to NMR equipment, am sure a few others (ERV perhaps) have too...hmm i see possibilities for my Blowfelt like plans to come together, now all i need is a private island and some a white pussy. MOOOWahahahahahahaha

[Mzone]

BarnOwl,

If you enjoyed the last video on Thorium, watch the first 8 minutes of this one, the next 1:30:00 flew by. This is the one that got me hooked and wanting to get involved. The great SJW warrior that I am :)

[youtube]D3rL08J7fDA[/youtube]

Mzone

[BarnOwl]

It's time to reprise this video!

[youtube]9C_11laqbvM[/youtube]

If I were feeling depressed, I would try watching that video as an initial self-medication. :lol:

[ConcentratedH2O, OM]

If you want a break from the tone trolling of Michael Nugent. Clean energy is near and dear to me and medical radioactive isotopes to treat cancers are in terribly short supply.

That was awesome - thanks for posting it!

I read some good news today regarding cancer treatment research. Years ago, as a postdoc, I developed and characterized a genetically engineered mouse model (GEMM) for an aggressive form of inherited cancer. It typically affects people who have the cancer syndrome when they're in their teens, or as young adults, and it is nearly impossible to treat effectively. Doesn't respond well to chemotherapy or radiotherapy (and the patient has a high risk of developing a secondary malignancy as a result of the treatment), and very difficult to remove completely with surgery. Over the years, with a number of collaborators, we used the GEMM to identify genes that might provide therapeutic targets. My lab looked at the genomic instability of the tumors, and of tissues that might develop secondary malignancies following radio- or chemotherapy to treat the primary tumor.

Well, today a friend sent me a link to a paper indicating that my postdoc mentor's current lab group has cured the tumors in the GEMM, with both genetic and pharmacological approaches. Cured them. Gone! Their next step is a clinical trial in humans who have this type of cancer, with the pharmacologic agent. Go SCIENCE!!!! :dance:

Anytime BarnOwl :) I am glad someone enjoyed it.

As for your mentor, that sounds like great news! Any views on http://www.nytimes.com/2013/02/12/scien ... anted=all&

I am hoping that GEMM is still a valid testing model for Cancer.

Mzone

Mzone: most scientists have always accepted that mice are not a perfect model of human diseases. How could they be? The only perfect model of human diseases is humans with those diseases. But it's really hard (impossible, outside of China) to get ethical approval to deliberately give 20 humans sepsis, and then try to cure them with a drug that no one has taken before. So, we make do with what we have.

This paper seems to make it clear just how different some diseases are between humans and mice. But, as I said, we make do with what we have while realizing that our models may be completely non-representative of the human equivalent.

It's probably a bit like asking an automotive engineer to design doors for a Rolls Royce, but only allowing them access to the design stats of a Ford Focus. Sometimes, they might also be given information such as "the car we want doors for is eighty percent longer and forty percent taller than the model you have", and sometimes the engineers will get smart/lucky and end up with doors that somewhat fit the Rolls Royce.

[Bourne Skeptic]

I don't think it can be emphasized enough that civil attempts at discussion have been made MANY MANY times, and are STILL being attempted (Justin Vacula being one example). It might surprise you but many of the people here were driven here after engaging in good faith at FTB or elsewhere...

I have great respect for Justin's patience, forbearance, and fortitude but I still don't see the need to engage. Look at the trajectory of traffic and membership here compared to FTB and A+. The defections are all in the same direction. To reiterate an earlier point, if you can remember the Cold War you should know that this can only end one way.

The fall of the berlin wall and the invasion of afghanistan and iraq? I don't see it coming to that (but i have heard that FtB are developing nuclear capability)

I heard it was a biological weapon, something having to do with PZ's socks!

Not coffee? Or is that our weapon? I forgot to check my backchannel - it was a bit blocked, so I may not have gotten the message.

Should our new motto be "Mr Myers, tear down that wall"?[/quote]

Groan :)

I wonder if PZ thinks he's getting hit on if a guy asks him out for coffee?

[Submariner]

[youtube]DRHIByOHhdA[/youtube]

Here you go Rocko. One from the old guy.

[Lurkion]

JUSTICAR COME BACK TO THE PIT.

[comslave]

Well, would you look at that. Ing is "spewing misogynistic hate" on Twitter, per Aratina's definition in his slandering of Windy yesterday.

http://i.imgur.com/HZrncGW.jpg

"Cuntfederacy", I'm keeping that.

[BarnOwl]

Congrats; bloody good show, eh! :-)

Must feel rather gratifying, to have been a significant part of that process – “one small [?] step for a woman; one rather large step for humanity” – and all that.

Out of curiousity, any links to that paper available or to related discussions? ….

Linky to PubMed abstract for the paper: http://www.ncbi.nlm.nih.gov/pubmed/23434321

Linky to news article: http://www.alnmag.com/news/mouse-model- ... ncer-cured

BarnOwl, thank you for your work in the field, and for the interesting reading!

I honestly can't express how much of a privilege it's been to work with all the other researchers, physicians, and patient advocates in the field - it's a great community.

I probably don't need to explain my cynicism about and frequent lack of sympathy for the FtB drama to my fellow 'Pitters, do I? Perspective, of course.

Plus I'm kind of a bitch. :D

[Patrick]

[youtube]DRHIByOHhdA[/youtube]

Here you go Rocko. One from the old guy.

So the old guy was filming that young whippersnapper in the video?

[Southern]

Hey, guess who finished the first part of her epic takedown on mysoginy over videogames?

Anita Snarkess, that's who.

[Submariner]

So the old guy was filming that young whippersnapper in the video?

Rocko seems to think I haven't aged gracefully.

[Southern]

Incidentally, every time I see the name "Anita", I remember Anita Garibaldi, who kicked much ass in battle alongside her husband Giuseppe until she died. This Sarkeesians is a shame to the good name of Anita. Begone, foul, whinny beast!

[Patrick]

So the old guy was filming that young whippersnapper in the video?

Rocko seems to think I haven't aged gracefully.

At least tell me your beard comes in gray.

[Submariner]

So the old guy was filming that young whippersnapper in the video?

Rocko seems to think I haven't aged gracefully.

At least tell me your beard comes in gray.

In patches. S&P.

[Aneris]

[...] I also think he is a prime example of the Dunning-Kreugar effect in action. He really thought people here were mindless trolls and moral delinquents. [...]

I don't know much about Nugent, but he might have gotten this impression from the baboonery. Over there, this view is deeply rooted. Waltz into any "difficult topic" and point out anything, and they infer that you must be a misogynist rapist from the slymepit. Their ingroup career is about finding a suitable foil that allows them to step onto the soapbox where they then peacock as social warriors proper. The narrative must be kept very simple, the outsider is evil, they are good as to not risk internal disagreement. Over time their fabrications seem entirely real to them, and they are always routinely associated with the slymepit. Its almost a christian dualism, where whatever negatively happens must be attributed to the devil. I think that Nugent is rather concerned now to find out that there are some more dimensions to it.

[Karmakin]

Hey, guess who finished the first part of her epic takedown on mysoginy over videogames?

Anita Snarkess, that's who.

How ironic that she starts with a trope that her entire ideology resolves around.

Actually, watching the video (and being a gamer) it's amazing to see how far things have come. The biggest recent example was, of course, Double Dragon Neon which was a retro throw-back (and how...to be fair, you should check out the ending credits. It's AWESOME). Of course, there was little to no acknowledgement of this. Personally, I agree that the "Damsel in Distress" trope is generally boring at this point, but it's not really a black or white thing.

[jimthepleb]

Hey, guess who finished the first part of her epic takedown on mysoginy over videogames?

Anita Snarkess, that's who.

woah $160,000 doesn't buy you much these does it?
Wholly underwhelming. mind you is AS was on screen with fireworks firing out of her arse it would still disappoint after the hype.

[Submariner]

[...] I also think he is a prime example of the Dunning-Kreugar effect in action. He really thought people here were mindless trolls and moral delinquents. [...]

I don't know much about Nugent, but he might have gotten this impression from the baboonery. Over there, this view is deeply rooted. Waltz into any "difficult topic" and point out anything, and they infer that you must be a misogynist rapist from the slymepit. Their ingroup career is about finding a suitable foil that allows them to step onto the soapbox where they then peacock as social warriors proper. The narrative must be kept very simple, the outsider is evil, they are good as to not risk internal disagreement. Over time their fabrications seem entirely real to them, and they are always routinely associated with the slymepit. Its almost a christian dualism, where whatever negatively happens must be attributed to the devil. I think that Nugent is rather concerned now to find out that there are some more dimensions to it.

As usual Aneris, I find your insights fascinating.

spockfascinating.jpg

(17.5 KiB) Downloaded 117 times

[Steersman]

Congrats; bloody good show, eh! :-)

Must feel rather gratifying, to have been a significant part of that process – “one small [?] step for a woman; one rather large step for humanity” – and all that.

Out of curiousity, any links to that paper available or to related discussions? ….

Linky to PubMed abstract for the paper: http://www.ncbi.nlm.nih.gov/pubmed/23434321

Linky to news article: http://www.alnmag.com/news/mouse-model- ... ncer-cured

BarnOwl, thank you for your work in the field, and for the interesting reading!

I honestly can't express how much of a privilege it's been to work with all the other researchers, physicians, and patient advocates in the field - it's a great community.

I’m in the midst of reading Complexity: The Emerging Science at the Edge of Order and Chaos (Waldrop) – highly recommended – but its description of the evolution of that science is decidedly fascinating. Feel some degree of envy towards those who are at the edges of such developments ….

I probably don't need to explain my cynicism about and frequent lack of sympathy for the FtB drama to my fellow 'Pitters, do I? Perspective, of course.

Social justice is, I think, quite a credible field of endeavor, but the tendency to make the drama an end in itself is rather problematic, and not particularly productive, and ultimately rather enervating. Reminds me of this:

Big whirls have little whirls that feed on their velocity,
And little whirls have lesser whirls and so on to viscosity.

Aka, sludge.

Plus I'm kind of a bitch. :D

Oh no! Stockholm Syndrome! The Pod People have gotten you!

Either that or it confirms your status as a “chill-girl” and a “gender-traitor” …. :-)

[Karmakin]

[youtube]ZJNDP_HTFp4[/youtube]

Huh. I didn't remember the very end. They don't do misogyny like they used to at all.

[Metalogic42]

Hey, guess who finished the first part of her epic takedown on mysoginy over videogames?

Anita Snarkess, that's who.

Just started watching this, because I'm a masochist. Wish me luck.

[Submariner]

Hey, guess who finished the first part of her epic takedown on mysoginy over videogames?

Anita Snarkess, that's who.

Just started watching this, because I'm a masochist. Wish me luck.

I only made it to about 1:13. Good luck.